| Artist | Title | Week Ending | Weeks There |
| Belinda Carlisle | Heaven Is A Place On Earth | 16 Jan 1988 | 2 |
| Tiffany | I Think We’re Alone Now | 30 Jan 1988 | 3 |
| Kylie Minogue | I Should Be So Lucky | 20 Feb 1988 | 5 |
| Aswad | Don’t Turn Around | 26 Mar 1988 | 2 |
| Pet Shop Boys | Heart | 9 Apr 1988 | 3 |
| S’Express | Theme from S’Express | 30 Apr 1988 | 2 |
| Fairground Attraction | Perfect | 14 May 1988 | 1 |
| Wet Wet Wet / Billy Bragg with Cara Tivey | With a Little Help from My Friends / She’s Leaving Home | 21 May 1988 | 4 |
| Timelords | Doctorin’ The Tardis | 18 Jun 1988 | 1 |
| Bros | I Owe You Nothing | 25 Jun 1988 | 2 |
| Glenn Medeiros | Nothing’s Gonna Change My Love for You | 9 Jul 1988 | 4 |
| Yazz and the Plastic Population | The Only Way Is Up | 6 Aug 1988 | 5 |
| Phil Collins | A Groovy Kind of Love | 10 Sep 1988 | 2 |
| Hollies | He Ain’t Heavy, He’s My Brother | 24 Sep 1988 | 2 |
| U2 | Desire | 8 Oct 1988 | 1 |
| Whitney Houston | One Moment in Time | 15 Oct 1988 | 2 |
| Enya | Orinoco Flow | 29 Oct 1988 | 3 |
| Robin Beck | The First Time | 19 Nov 1988 | 3 |
| Cliff Richard | Mistletoe and Wine | 10 Dec 1988 | 4 |
